The Impact of Lead (Pb) on Health
DOI:
https://doi.org/10.30994/jgrph.v10i1.549Keywords:
Behavioral disorders, Cognitive impairment, Health impact, Lead exposure, Public healthAbstract
This systematic literature review aims to evaluate the neurodevelopmental, behavioral, and physiological impacts of lead (Pb) exposure in both children and occupationally exposed populations. Using the PRISMA framework, we reviewed 13 peer-reviewed studies published between 2013 and 2023. The studies include a range of methodologies- longitudinal, cross-sectional, experimental, and systematic reviews assessing lead exposure’s health effects. Databases were screened based on inclusion criteria focused on cognitive, behavioral, or physiological outcomes linked to lead levels in blood or tissues. Across studies, childhood lead exposure was consistently associated with lower intelligence scores, behavioral disorders (e.g., aggression, hyperactivity, depression), and increased risks for mental health conditions. Occupational exposure, particularly among gas station workers and forecourt attendants, was linked to chronic fatigue, sleep disturbances, and potential neurodegenerative conditions like ALS. The neurotoxic mechanisms included oxidative stress, neurotransmitter disruption, and long-term accumulation in bones. Notably, even low-level lead exposure resulted in significant adverse effects, with no safe threshold identified. These findings underline the critical need for public health interventions including environmental regulation, routine blood lead screening, protective workplace protocols, and early childhood monitoring. Prevention and awareness programs are essential to reduce lifelong harm from lead exposure, particularly in vulnerable populations.
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References
Arianty, M., Beatrice, M., & Wulandari, S. (2020). Pajanan Timbal Terhadap Tingkat Kesehatan Anak. Scientific Journal of Public Health: Public Health Community Communication Media , 12 (2), 89–98. https://doi.org/10.52022/jikm.v12i2.59
Bell, W., & O'Grady, K. (2004). Lead poisoning in children. CMAJ : Canadian Medical Association Journal = Journal de l'Association Medicale Canadienne , 171 (5), 18–24.
Cahyono, EA, Sutomo, & Harsono, A. (2019). Literature Review: Writing and Compilation Guidelines. Journal of Nursing , 12.
Centers for Disease Control and Prevention (CDC), Recommendations For Blood Lead Screening of Young Children Enrolled in Medicaid: Tireedng. Group st High Risk. MMWR 2000i 49: l-13
Denny, L, 2009. Study of Policy Concept to Reduce Road Transportation Pollutant Emissions in Urban Indonesia to Maintain Air Quality and Public Health in the Perspective of Sustainable Transportation Development. Vol. 21, No. 2, 2009.
Devi Nuraini Santi. (2001). Air Pollution by Lead (Pb) and Its Control. 1–6.
Fadli, MR (2021). Understanding the design of qualitative research methods. Humanika, Scientific Study of General Courses , Vol. 21. N . https://doi.org/10.21831/hum.v21i1. 38075. 33-54
Gusnita, D. (2012). Heavy metal lead (Pb) pollution in the air and efforts to eliminate leaded gasoline. Aerospace News , 13 (3), 95–101.
Haddaway, N. R., Page, M. J., Pritchard, C. C., & McGuinness, L. A. (2022). PRISMA2020: An R package and Shiny app for producing PRISMA 2020-compliant flow diagrams, with interactivity for optimised digital transparency and Open Synthesis Campbell Systematic Reviews, 18, e1230. https://doi.org/10.1002/cl2.1230
Hou, S., Yuan, L., Jin, P., Ding, B., Qin, N., Li, L., Liu, X., Wu, Z., Zhao, G., & Deng, Y. (2013). A clinical study of the effects of lead poisoning on the intelligence and neurobehavioral abilities of children. Theoretical Biology and Medical Modelling , 10 (1), 1–9. https://doi.org/10.1186/1742-4682-10-13
Habsy, BA (2017). The Art of Understanding Qualitative Research in Guidance and Counseling: Literature Study. JURKAM: Andi Matappa Counseling Journal, 1(2), 90. https://doi.org/10.31100/jurkam.v1i2.56
Hasanah, N. (2022). Heavy Metal Contamination of Lead (Pb) In Local Food Bilvaves. Public Health Nutrition Media , 11 (2), 589–594. https://doi.org/10.20473/mgk.v11i2.2022.589-594
Humairo, MV, & Keman, S. (2017). Blood lead levels and central nervous system complaints in Unipress Surabaya printing workers. Journal of Environmental Health , 9 (1), 48–56.
Ir. Lilis Marwiani, M. (2021). The Impact of Lead Exposure on Children's Health https://sib3pop.menlhk.go.id/index.php/articles/view?slug=dampak-paparan-timbal-pada-kesehatan-anak
Kustiningsih, Y., Thomas, N.F., & Rahardian, T.D. (2020). Kadar Timbal Darah pada Kesehatan Anak. Jurnal Kesehatan Masyarakat, 2(2), 119-124. https://doi.org/10.37287/jppp.v2i2.54
Lanphear, B. P. (2015). The impact of toxins on the developing brain. Annual Review of Public Health , 36 , 211–230. https://doi.org/10.1146/annurev-publhealth-031912-114413
Marianti, A, & Prasetya, A. . (2013). Hair as a Bioindicator of Lead Pollution in Residents in North Semarang District . 5 (1), 11–15. http://journal.unnes.ac.id/nju/index.php/biosaintifika
Marianti, Aditya, Anies, A., & Abdurachim, HRS (2015). Increased Blood Lead Levels and the Emergence of Antisocial Behavior in Brass Craftsmen. Journal of Public Health , 11 (1), 144. https://doi.org/10.15294/kemas.v11i1.3730
Mohandoss, A., & Thavarajah, R. (2017). An audit of Indian health insurance claims for mental illness from pooled insurance information bureau’s macroindicator data. Indian Journal of Psychological Medicine, 39(3), 254–261. https://doi.org/10.4103/0253-7176.20734
Nurjazuli, Darundiati, YH, & Wardoyo, S. (2021). Paparan Logam Plumbum (Pb) sebagai Pemicu Stunting pada Balita: Literature Review. Poltekita: Journal of Health Sciences , 15 (3), 37–43. https://doi.org/10.33860/jik.v15i3.508
Naria, E. (2005). Being Aware of the Impact of Lead (Pb) Pollutants in the Environment on Health. Journal of Research Communication , 17 (4), 67.
Prasetya, HR (2021). Hubungan Timbal Darah Terhadap Kelainan Sel Darah Pada Anak Jalanan Di Kota Yogyakarta. Meditory: The Journal of Medical Laboratory , 9 (1), 44–53. https://doi.org/10.33992/m.v9i1.1291
Purwoko, D., & Prastiwi, DE (2019). The Effect of Location and Time of Measurement of Moving Sources (Vehicles) with Lead (Pb) Content in the Air at Simpang Lima Mandai, Makassar City. Sulolipu: Media Communication for Academics and Society , 17 (2), 39. https://doi.org/10.32382/sulolipu.v17i2.825
Reffiane, F., Arifin, MN, & Santoso, B. (2012). The Impact of Lead (Pb) Content in Air on the Intelligence of Elementary School Children. Malih Peddas (Elementary Education Scientific Magazine) , 1 (2). https://doi.org/10.26877/malihpeddas.v1i2.305
Reuben, A., Schaefer, J.D., Moffitt, T.E., Broadbent, J., Harrington, H., Houts, R.M., Ramrakha, S., Poulton, R., & Caspi, A. (2019). Association of childhood exposure with adult personality traits and lifelong mental health. JAMA Psychiatry , 76 (4), 418–425. https://doi.org/10.1001/jamapsychiatry.2018.4192
Ramírez Ortega, D., González Esquivel, D.F., Blanco Ayala, T., Pineda, B., Gómez Manzo, S., Marcial Quino, J., Carrillo Mora, P., & Pérez de la Cruz, V. (2021 ). Cognitive impairment induced by lead exposure during lifespan: Mechanisms of lead neurotoxicity. Toxics , 9 (2), 1–30. https://doi.org/10.3390/toxics9020023
Ridwan, M., AM, S., Ulum, B., & Muhammad, F. (2021). The Importance of Applying Literature Review in Scientific Research. Jurnal Masohi , 2 (1), 42. https://doi.org/ 10.36339/jmas.v2i1.427
Salsabilla, RO, Pratama, B., & Angraini, DI (2020). The Kadar Timbal Darah pada Kesehatan Anak. Journal of Professional Nursing Research , 2 (2), 119–124. https://doi.org/10.37287/jppp.v2i2.54
Sari, BT, & Lubis, B. (2014). The Relationship Between Lead Poisoning and Iron Deficiency Anemia in Children. Indonesian Medical Journal , 47 (3), 164–167.
Syahrizal, D. (2009). The Effect of Plumbum (Pb) on Child Development. Syiah Kuala Medical Journal , 9 (1), 49–54
Santi, DDN (2001). Air Pollution by Lead (Pb) and its Control Dr. Devi Nuriini Santi. 1–6.
Satmiadji, E., Priyanta, M., Anasya, CS, Zulkaranain, Mariane, I., Wibisana, AG, Syharani, Purwendah, EK, Rahmat, Siombo, MR, Naiborhu, NS ., Hermawan, S., & Wardana, A. (2022). Citizen Lawsuit in Indonesia: A Review of Substance, Procedure, and Execution (N. Astriani, Nadia Dzabiyyah (eds.)). https://icel.or.id/wp-content/uploads/2023/03/Citizen-Lawsuit-di-Indonesia-Tinjauan-terhadap-Substansi-Prosedur-Serta-Eksekusi.pdf#page=11
Setiawati, Y., et al. (2020). Pengaruh Timbal dan Zinc pada Attention Deficit Hyperactivity Disorder (ADHD). Jurnal Penelitian Perawat Profesional, 2(2), 119-124. https://doi.org/10.37287/jppp.v2i2.54
Susantyo, B. (2011). Understanding Aggressive Behavior: A Conceptual Review. Sosio Informa , 16 (3), 189–202. https://doi.org/10.33007/inf.v16i3.48
Simbolon, AR (2018).Analisis Risiko Kesehatan Pencemaran Timbal (Pb) Pada Kerang Hijau (Perna viridis) di Perairan Cilincing Pesisir DKI Jakarta . Oceanology and Limnology in Indonesia , 3 (3), 197. https://doi.org/10.14203/oldi.2018.v3i3.207
UNICEF. (2020). Mengurangi Keracunan Timbal pada Anak-Anak di Indonesia: Ringkasan Kebijakan. [PDF]. https://www.unicef.org/indonesia/media/15311/file/Ringkasan%20Kebijakan%20-%20Mengurangi%20Keracunan%20Timbal%20pada%20Anak-anak%20di%20Indonesia.pdf
Wirsal, H. (2012). Prevention of Chronic Lead Poisoning in Adult Workers with Calcium Supplements. Makara Health , 16 (1), 1–8
Anusa, M., & Rooban, T. (2017). Burden of exposure to lead as a risk factor for mental illness in Indian children 1990–2015: A systematic analysis based on global burden of disease approach. Annals of Indian Psychiatry, 1(2), 88. https://doi.org/10.4103/aip.aip_22_17
Grover, S., & Jhanda, S. (2017). Lead and its association with mental illness. Annals of Indian Psychiatry, 1(2), 62. https://doi.org/10.4103/aip.aip_44_17
